Statistical parametric maps of BPND of 11C-(R)-PK11195 in CFS.ME patients and healthy controls

Autor:

Yasuhito Nakatomi, Kei Mizuno, Akira Ishii, Yasuhiro Wada, Masaaki Tanaka, Shusaku Tazawa, Kayo Onoe, Sanae Fukuda, Joji Kawabe, Kazuhiro Takahashi, Yosky Kataoka, Susumu Shiomi, Kouzi Yamaguti, Masaaki Inaba, Hirohiko Kuratsune and Yasuyoshi Watanabe

This research was originally published in JNM. Author(s). Title. J Nucl Med. 2014;vol:55-no.6 945-950. © SNMMI.

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http://jnm.snmjournals.org/content/55/6/945.long

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FIGURE 2.

Statistical parametric maps of BPND of 11C-(R)-PK11195 in CFS/ME patients and healthy controls. Anatomic locations were mapped on template brains. Peak coordinates (−6, −22, −4) correspond to intralaminar nucleus of left thalamus. BPND of this coordinate for each individual in CFS/ME and HC groups is plotted in bottom right panel. ***P < 0.0001 (Student t test). HC = healthy control.

The SPM analysis also revealed significantly higher 11C-(R)-PK11195 BPND in CFS/ME patients than in healthy controls in the left thalamus, midbrain, and pons (Fig. 2). The Montréal Neurologic Institute coordinates of peak 11C-(R)-PK11195 BPND (highest t score on SPM5) in the CFS/ME group corresponded to the intralaminar nucleus of the left thalamus (−6, −22, −4) and midbrain (−4, −30, −14). In the CFS/ME group, the peak value of 11C-(R)-PK11195 BPND in the left thalamic intralaminar nucleus (−6, −22, −4) was positively correlated with the cognitive impairment score (r = 0.86; P = 0.0028) and tended to be positively correlated with the VAS score for fatigue sensation (r = 0.63; P = 0.0683), and the peak value of 11C-(R)-PK11195 BPND in the midbrain (−4, −30, −14) was positively correlated with the cognitive impairment score (r = 0.72, P = 0.0293).

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